10 Options in Treating Mesothelioma

By: Paul Wilson

As with any cancer, treatment for Mesothelioma depends on the location of the cancer, the progression of the disease, the age as well as state of health of the patient.

It is the oncologist who specializes in the disease who will decide on the line of treatment. The disease is difficult to treat and in most cases the prognosis is poor. Treatment options include:

1. If the diagnosis is done in the early stages surgery may be recommended to remove all cancerous tissues. This means thoracoscopy, VATS or video assisted thoracic surgery, mediastinoscopy (used for staging), or laproscopy. Often, doctors will advise palliative procedures like chest tube drainage and pleurodesis, thoracoscopy and pleurodesis, pleuroperitonial shunt, or pleurectomy, which treat the symptoms of mesothelioma rather than the disease.

2. Radiation is prescribed aggressively for mesothelioma patients and is often given in combination with surgery or in order to control symptoms, palliatively. Research on using radiation therapy using implants or UV light therapy is in progress as traditional radiation therapy damages surrounding healthy tissue.

3. Chemotherapy is an option and around 12-20% of patients respond to the drugs. Anti-cancer drugs destroy cancer cells and prevent their spread. In mesothelioma, chemotherapy is not considered to be curative. The aim is to prevent spread of the disease; shrink the tumor prior to surgery, known as neoadjuvant therapy; to annihilate any remains of the tumor in the body post surgery; and to relieve pain and other discomfort, palliative chemotherapy. Experts recommend prescribing premetrexed along with cisplastin. These drugs have shown positive results and this is now standard care for Mesothelioma not treatable by surgery.

4. Biological therapy using interleukin 2.

5. Immunotherapy where the body’s own immune system is stimulated to fight the disease. Biological response modifiers, BRMs, are used in treatment. These enhance the functions of the immune system; regulate metabolic reactions that promote growth of cancers; alter cancer cell division; block or reverse processes that lead to formation of cancers; and prevent spread of cancer.

6. Gene therapy, where attempts are made to correct the gene sequence that causes the cancer. This is of two kinds, replacement gene therapy and knockout gene therapy.

7. Administration of lovastatin, a cholesterol lowering drug.

8. Photodynamic treatment where a photosensitive medication is activated using a laser. This is done during the surgical removal of cancerous tissues.

9. Draining of fluid in the chest or abdominal cavity followed by introduction of medications into the cavity to prevent fluid accumulation is done for patients who have uncontrolled fluid accumulation and intense discomfort stemming from it.

10. Combination therapy or Trimodal therapy which means surgery accompanied by radiation and chemotherapy.

Often, complementary medicines are also used. Termed to be holistic this kind of treatment focuses on a patient’s physical, mental, emotional, and spiritual well being.

In the case of Mesothelioma which is untreatable one can opt for clinical trials of new treatments that are in progress in several research laboratories and centers. The best advice on the line of treatment would be that recommended by the oncologist or physician.

Article Source: http://www.articlecube.com

Mesothelioma a cancer caused by asbestos

By: Paul Wilson

The internal organs of the human body are encased in a protective sac called the mesothelium. Examples of mesothelilial membranes are the peritoneum (abdominal organs), pleura (lungs), and pericardium (heart).

Under specific conditions, the cells of the protective membrane divide uncontrolled and become cancerous. This disease is termed as Mesothelioma, a rare form of cancer which is caused by prolonged exposure to asbestos dust.

The disease is found to occur among those who work in shipyards, asbestos mines and factories, industries that produce asbestos based products, and the heating and construction businesses. Approximately 3,000 cases occur each year in the US, and most patients are between 50-70 years old. Statistics show that males are commonly affected and among them whites more than African Americans.


First studied in the late 1700s in depth studies were only done in the 1960s. Tumors of the Mesothelioma can be benign or malignant. The malignant Mesothelioma are categorized into three types:

• Epithelioid, accounting for 50-70% of mesotheliomas.

• Sarcomatoid, accounting for 7-20%.

• Mixed or bi-phasic, accounting for 20-35%.

When asbestos fibers are breathed into the lungs they travel through large air passages to reach the smaller passages and from them the pleura. In the pleura they damage: the mesothelial cells leading to cancer; lung tissue causing lung cancer; and the development of scar tissue within the lungs known as asbestosis. When asbestos fibers are swallowed they reach the abdominal cavity and cause peritoneal mesothelioma.

Research reveals that the disease only manifests 20-50 years after being exposed to asbestos dust. The symptoms are not specific to the disease but a patient may develop:

• Breathlessness.

• Chest pain accompanied by tightness believed to be caused by accumulation of fluid in the pleura.

• Low back pain.

• Swelling of face and arms.

• Sensory loss.

• Muscle weakness.

• Nausea.

• Vomiting.

• Weight loss that is unexplained.

• Persistent dry cough.

• Sore throat.

• Anemia.

• Fever.

• Constipation.

• Problems with blood clotting.

Since the above are common to minor ailments, patients often ignore the symptoms. It is advisable to consult a doctor if any of the above symptoms persist or if you feel you have been knowingly or unknowingly exposed to asbestos.

A doctor will:

• Take down a detailed medical history and try and determine the symptoms and risk factors.

• Do a thorough physical examination and check for signs of:

o Pleural effusion, fluid accumulated in the chest cavity.

o Fluid in the abdominal cavity.

o Pericardial effusion, fluid in the lining of the heart.

• Take a chest x-ray and check for thickening of the pleura, calcifications, and lowered lung fissures.

• Ask for a CT scan to determine clearly the location, size, and extent of the problem if any is suspected.

• Recommend tests of tissue samples and pleural fluids.

Other risk factors are cigarette or cigar smoking, exposure to radiation, exposure to zeolite a compound that is similar to asbestos, exposure to or infections caused by SV40, a Simian virus.

Those who work in a risky environment should wear protective clothing, have the surroundings tested regularly for suspended asbestos particles, and ensure that they have regular medical tests and report to the doctor any ailments that persist.

Being aware of the disease and its problems helps.

Article Source: http://www.articlecube.com